By Qin Wang
This quantity of present issues in Membranes specializes in Adrenergic Receptor Biology, starting with a assessment of prior successes and old views then additional discussing present normal developments in adrenic receptor experiences in quite a few contexts. This e-book additionally comprises discussions of the position and courting of adrenergic receptors to varied structures and illnesses, developing Adrenergic Receptor Biology as a wanted, sensible reference for researchers.
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Extra info for Advances in Adrenergic Receptor Biology
Recent studies have even challenged the basic definitions of pharmacological efficacy, in that ligands defined as agonists, antagonists, or inverse agonists for a given signaling pathway may not necessarily exhibit similar effects in other signaling pathways. The ability of different ligands to discriminate between signaling pathways coupled to a given GPCR has been termed ‘‘biased’’ agonism (Kenakin, 2010). Such biased signaling has been well demonstrated for all three bAR subtypes. For example, work from Michel Bouvier’s group has shown that different bAR agonists have differing abilities to activate two signaling pathways downstream of both the b1AR and the b2AR, that is AC activation and ERK1/2 MAP kinase activation.
2002; Wang, Wu, Ge, Ma, & Pei, 2003), GRKs (Yi, Gerdes, & Li, 2002; Johnson, Scott, & Pitcher, 2004; Yi, Zhou, Baker, Wang, Gerdes, & Li, 2005), A kinase anchoring proteins (AKAPs), and PKA (Sastri, Barraclough, Carmichael, & Taylor, 2005), among others, have been demonstrated to be trafficked to the nucleus and/or nuclear membrane. Interestingly, enzymes involved in the generation and metabolism of phosphoinositides (Barlow, Laishram, & Anderson, 2010) or processing peptide ligands such as ACE have also been localized to the nuclei of different cell types (Lucero, Kintsurashvili, Marketou, & Gavras, 2010).
Perkins, J. P. (1979). Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma. cells Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors. J Biol Chem, 254, 38–41. Tan, C. , Wilson, M. , MacMillan, L. , Kobilka, B. , & Limbird, L. E. (2002). Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proc Natl Acad Sci USA, 99, 12471–12476. , & Kenakin, T. (2010). The role of conformational ensembles of seven transmembrane receptors in functional selectivity.
Advances in Adrenergic Receptor Biology by Qin Wang