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Download e-book for iPad: Advances in Genetics, Vol. 23 by E.W. Caspari, John G. Scandalios (Eds.)

By E.W. Caspari, John G. Scandalios (Eds.)

ISBN-10: 0120176238

ISBN-13: 9780120176236

This quantity in a sequence on genetics, emphasizes the range of genetic reviews. Articles hide the filamentous fungus neurospora, biogenesis of yeast ribosomes, evolutionary genetics of fish, drosophila transposable parts and the dropophila gene zeste.

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E Birnboim and Nasim (1974, 1975). f Schupbach (1971); Grossenbacher-Grunder and Thuriaux (1981). g Grossenbacher-Grunder and Thuriaux (1981). Gentner et al. (1978). Gentner (1977). a 26 J. PHIPPS et al. TABLE 3 The Response of Double Mutants to Inactivation by UV Irradiationa Parental strains used in the genetic crossb rad rad rad rad rad rad rad 1 3 2 2 3 10 10 x rad 10 X x x x x x rad rad rad rad rad rad 13 13 3 Radiation sensitivity of the double mutantC t + - t 9 11 - 13 - t From Nasim and Smith (1974).

The independence of mutational and lethal damage had, however, been demonstrated earlier by Nasim and Saunders (1968). Abbondandolo and Simi (1971) suggested that the lethal sectoring hypothesis would be relevant at high levels of killing but a repair mechanism would be active at high survival rates. RECOVERY AND REPAIR IN Schizosaccharomyces 47 The contribution of lethal sectoring was ruled out, for UV a t least, by Hannan et al. (1976a) using a G, haploid population of S. cereuisiae and by James and Kilbey (1977) using pedigree analysis.

The most popular is probably the a-p model of Chadwick and Leenhouts (19731, in which two types of potentially lethal damage are postulated, one requiring a single event (the a term) and the other a n interaction of two events (the p term). These lead to an exponential or a shouldered region of the survival curve, respectively. If the second suggestion of Hannan et al. (1976b), that two 38 J. PHIPPS et al. mechanisms influence survival during liquid holding, is valid, a n apparently exponential survival curve, as seen for example with certain sensitive strains irradiated in logarithmic growth conditions, would appear as a shouldered curve for resistant strains.

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Advances in Genetics, Vol. 23 by E.W. Caspari, John G. Scandalios (Eds.)


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